Because during the TCA Cycle (aka Kreb’s Cycle), energy is both consumed and produced. During the TCA cycle, acetyl coA is converted to CO2 and H2O but. The citric acid cycle is the central metabolic hub of the cell. It is the final common pathway for the oxidation of fuel molecule such as amino acids. Amphibolic Nature Of TCA Cycle: In aerobic organisms, the citric acid cycle is an amphibolic pathway, one that serves in both catabolic and anabolic processes.

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Intermediates of TCA cycle are utilised for synthesis of various compounds. Your email address will cgcle be published. Notify me of follow-up comments by email.

Notify me of new posts by email. Home Metabolism Amphibolic Nature of the Citric acid cycle.


TCA Cycle is a open cyclic process: TCA cycle is a cyclic process. Being the open cyclic process, there is no compulsion of Acetyl CoA to start the cycle.

amphibolic nature of citric acid cycle | Medical Study Stuff and Accessories

The cycle can initiate from any of the intermediate. The diagram representing amphibolic and open cyclic process Ntaure detail: Synthesis of non-essential amino acids: Because these reactions are reversible, TCA cycle serves as a source of C-skeletons for the synthesis of nonessential amino acids.

Other amino acids contribute to gluconeogenesis because all or part of their C-Skeletons enter TCA cycle after deamination or transamination. Pyruvate forming amino acids: Arginine, histidine, glutamine and proline. Fumarate forming amino acids: Phenylalanine and tyrosine Succinyl-CoA forming amino acids: Valine, Methionine and Isoleucine.

Acetyl-CoA is impermeable to mitochondrial membrane and hence it has to be transported out. Synthesis of cholesterol and steroids: Acetyl-CoA is used for synthesis of cholesterol, which in turn is required for synthesis of steroids.


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