leucemia linfocítica crónica (CLL, por sus siglas en inglés), preparar preguntas informadas .. clasificación. Cada uno de estos tipos de cáncer. Leucemias agudas mieloblásticas. Clasificación. Etiopatogenia. French- American- British (FAB) Cooperative Group. Br J Haematol, 33 (), pp. In , the consensus that led to the French-American-British (FAB) classification was achieved. .. Clasificacion de las leucemias agudas mieloides. Rev Lab.

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The aim of any lymphoma classification is to provide an international language allowing communication. The classification must be reproducible and clinically relevant, and sufficiently flexible to permit the incorporation of new data. Finally, the classification must be histopathologically based because it is the pathologist who, in most instances, makes the initial diagnosis. The current WHO classification of lymphoid neoplasms represents a major step forward in our understanding of these tumours.

This classification highlights the stage of differentiation of the tumour cell, grouping neoplasms by morphology, histology, leucwmias, cytogenetic, molecular abnormalities and clinical data.

The category of diffuse large B-cell lymphoma is heterogeneous, including several subtypes. The molecular biological characteristics are, in general, well defined in small cell B-cell lymphomas, such as chromosomal translocations involving the immunoglobulin heavy chain genes and the Bcl-2 gene or Cyclin D1 gene. In these review, the characteristics important for the diagnosis and categorisation of B-cell lymphomas will be summarised.

Further, we present information regarding the molecular biological and clinical characteristics of these lymphomas. En clasificaion caso de los linfomas B, estas definiciones toman aun mayor valor. Ocasional presencia discreta de componente M en suero. Deleciones de 13q14, distales al gen de retinoblastoma.

No existen datos que justifiquen reconocer esta variante como una enfermedad diferente.

Frecuente anemia y trombocitopenia. Es una enfermedad relativamente agresiva con pobre respuesta a la quimioterapia convencional.

Pacientes adultos con esplenomegalia, pancitopenia y usualmente linfocitosis tumoral discreta. La proteinuria monoclonal puede conducir a fallo renal. Se suelen identificar Cuerpos de Dutcher inclusiones nucleares fig. Inmunocitoma con presencia de cuerpos de Dutcher nucleares flecha.

Es un tumor indolente, no curable. Pueden registrarse remisiones prolongadas en los tumores de bajo grado. Es una enfermedad moderadamente agresiva, no curable. Es una enfermedad de adultos, con ligero predominio de mujeres. Ausencia fzb t 11; 14o t 14; Esplenomegalia, con grado variable de linfocitosis y pancitopenia. Incluye localizaciones ganglionares y extraganglionares, enfermedades primarias y leucemizs.


Recientes estudios parecen confirmar la heterogeneidad molecular de este conjunto de enfermedades. Linfoma primario asociado a efusiones: EBV puede encontrarse en un porcentaje variable de casos. Los linfomas de Burkitt asociados a inmunodeficiencia HIV y otros se manifiestan con mayor frecuencia como enfermedad ganglionar.

A revised European-American classification of lymphoid neoplasms: Evaluation of the Revised European-American Lymphoma classification confirms the clinical clasidicacion of clasificacjon in cases of aggressive non-Hodgkin’s lymphoma. A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin’s lymphoma. New approach to classifying non-Hodgkin’s lymphomas: Non-Hodgkin’s Lymphoma Classification Project.

Pathology and genetics of tumours of haematopoietic and lymphoid tissues. World health organization classification of tumours. Extramedullary tumors of lymphoid or myeloid blasts.

ATLAS DE LEUCEMIAS | perdo sanchez –

The role of immunohistology in diagnosis and classification. Am J Clin Pathol. Molecular evidence of minimal residual disease after ls for leukaemia and lymphoma: Cytogenetic studies in seventy-six cases of B-chronic lymphoproliferative disorders. Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities.

N Engl J Med. ZAP expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.

Unmutated immunoglobulin variable heavy-chain gene status remains an adverse prognostic factor after autologous stem cell transplantation for chronic lymphocytic leukemia.

Translocation t 11;14 q13;q32 in chronic lymphoid disorders. A heterogeneous group that includes an unusual variant of mantle cell lymphoma. Immunohistochemical detection of cyclin D1 using optimized conditions is highly specific for mantle cell lymphoma and hairy cell leukemia.

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Clinical significance of the translocation 11;14 q13;q32 in multiple myeloma. Prognostic value of numerical chromosome aberrations in multiple myeloma: A FISH analysis of 15 different chromosomes. Clinicopathological definition of Waldenstrom’s macroglobulinemia: Chromosomal rearrangement of the PAX-5 locus in lymphoplasmacytic lymphoma with t 9;14 p13;q Cell cycle clasificzcion in B-cell lymphomas.

Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression alterations. A significant diffuse component predicts for inferior survival in grade 3 follicular lymphoma, but cytologic subtypes do not predict survival. Cutaneous presentation of follicular lymphomas.

Nonimmunoglobulin gene hypermutation in germinal center B cells. Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations. The molecular signature of mantle cell lymphoma reveals multiple signals favoring cell survival.

clasificacion de leucemias segun la fab.pdf

The t 11;18 q21;q21 chromosome translocation is a frequent and specific aberration in low-grade but not high-grade malignant non-Hodgkin’s lymphomas of the mucosa-associated lymphoid tissue MALT- type. Variable frequencies clasificafion t 11;18 q21;q21 in MALT lymphomas of different sites: BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma.


Primary nodal marginal zone lymphomas of splenic and MALT type. Am J Surg Pathol. Marginal zone B-cell lymphoma: A clinical comparison of nodal and mucosa-associated lymphoid tissue types. Marginal zone-related neoplasms of splenic and nodal origin.

Nodal marginal zone lymphoma: Nodal marginal zone B-cell lymphomas may arise from different subsets of marginal zone B lymphocytes. Unique phenotypic profile clasiticacion monocytoid B cells: Catovsky D, Matutes E.

clasificacion de leucemias segun la – PDF Files

Progression to large B-cell lymphoma in splenic marginal zone lymphoma: Splenic marginal zone lymphoma: A clinicopathological study of 13 cases. The histopathology of splenic lymphoma with villous lymphocytes. Intrasinusoidal bone marrow infiltration: Patterns of bone marrow involvement in 58 patients presenting primary splenic marginal zone lymphoma with or without circulating villous lymphocytes.

Frequent involvement of chromosomes 1, 3, 7 and 8 in splenic marginal zone B-cell lymphoma. Splenic marginal zone B-cell lymphomas: Novel genomic imbalances in B-cell splenic marginal zone lymphomas revealed by comparative genomic hybridization and cytogenetics. Genomic abnormalities acquired in the blastic transformation of splenic marginal zone Dd lymphoma. Leycemias of the IgV H somatic mutations in splenic marginal zone lymphoma defines a fe of unmutated cases with frequent 7q deletion and adverse clinical course.

Analysis of immunoglobulin genes in splenic marginal zone lymphoma suggests ongoing mutation. Molecular heterogeneity of splenic marginal zone lymphomas: Splenic small B-cell lymphoma with predominant red pulp involvement: Splenic marginal zone lymphoma with increased number of blasts: The BCL6 gene in B-cell lymphomas with 3q27 translocations is expressed mainly from the rearranged allele irrespective of the partner gene.

Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma.

Mediastinal large B-cell lymphoma: Detection by the fluorescence in situ hybridization technique of MYC translocations in paraffin-embedded lymphoma biopsy samples. Mechanism of activation and biological role of the c-myc oncogene in B-cell lymphomagenesis. Ann N Y Acad Sci. Molecular biology of Burkitt’s lymphoma.